Revelation 16:13

The sixth angel poured out his vial; and observe,

I. Where it fell - upon the great river Euphrates. Some take it literally, for the place where the Turkish power and empire began; and they think this is a prophecy of the destruction of the Turkish monarchy and of idolatry, which they suppose will be effected about the same time with that of the papacy, as another antichrist, and that thereby a way shall be made for the conveniency of the Jews, those princes of the east. Others take it for the river Tiber; for, as Rome is mystical Babylon, Tiber is mystical Euphrates. And when Rome shall be destroyed her river and merchandise must suffer with her.

II. What did this vial produce? 1. The drying up of the river, which furnished the city with wealth, provisions, and all sorts of accommodations. 2. A way is hereby prepared for the kings of the east. The idolatry of the church of Rome had been a great hindrance both to the conversion of the Jews, who have been long cured of their inclination to idols, and of the Gentiles, who are hardened in their idolatry by seeing that which so much symbolizes with it among those called Christians. It is therefore very probable that the downfall of popery, removing these obstructions, will open a way for both the Jews and other eastern nations to come into the church of Christ. And, if we suppose that Mahomedism shall fall at the same time, there will be still a more open communication between the western and eastern nations, which may facilitate the conversion of the Jews, and of the fulness of the Gentiles. And when this work of God appears, and is about to be accomplished, no wonder if it occasion another consequence, which is, 3. The last effort of the great dragon; he is resolved to have another push for it, that, if possible, he may retrieve the ruinous posture of his affairs in the world. He is now rallying his forces, recollecting all his spirits, to make one desperate sally before all be lost. This is occasioned by the pouring out of the sixth vial. Here observe, (1.) The instruments he makes use of to engage the powers of the earth in his cause and quarrel: Three unclean spirits like frogs come forth, one out of the mouth of the dragon, another out of the mouth of the beast, and a third out of the mouth of the false prophet. Hell, the secular power of antichrist, and the ecclesiastical power, would combine to send their several instruments, furnished with hellish malice, with worldly policy, and with religious falsehood and deceit; and these would muster up the devil's forces for a decisive battle. (2.) The means these instruments would use to engage the powers of earth in this war. They would work pretended miracles, the old stratagem of him whose coming is after the working of Satan, with all power, and signs, and lying wonders, and with all deceivableness of unrighteousness, Th2 2:9, Th2 2:10. Some think that a little before the fall of antichrist the popish pretence of power to work miracles will be revived and will very much amuse and deceive the world. (3.) The field of battle - a place called Armageddon; that is, say some, the mount of Megiddo, near to which, by a stream issuing thence, Barak overcame Sisera, and all the kings in alliance with him, Jdg 5:19. And in the valley of Megiddo Josiah was slain. This place had been famous for two events of a very different nature, the former very happy for the church of God, the latter very unhappy; but it shall now be the field of the last battle in which the church shall be engaged, and she shall be victorious. This battle required time to prepare for it, and therefore the further account of it is suspended till we come to the nineteenth chapter, Rev 19:19, Rev 19:20. (4.) The warning which God gives of this great and decisive trial, to engage his people to prepare for it, Rev 16:15. It would be sudden and unexpected, and therefore Christians should be clothed, and armed, and ready for it, that they might not be surprised and ashamed. When God's cause comes to be tried, and his battles to be fought, all his people shall be ready to stand up for his interest and be faithful and valiant in his service.

Cross-references: 2Thess 2:9 · 2Thess 2:10 · Judg 5:19 · Rev 19:19 · Rev 19:20 · Rev 16:15